It looks like to me that the offset bores would change timing a few degrees due to a change in TDC in relation to the bore to crank.
If the motors TDC was at "0" and the bore offset moved two pistons cylinder bores 2 degrees (guess) forward and 2 cylinder 2 degrees back from center the motor would be firing the back cylinders early and the forward cylinders late.
I would think that there would need to be a timing compensation if the bores were moved....or if the cylinders were in a V, TDC would stay the same.
Again I am just thinking this and dont really know if this is valid.